Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model마우스 모델에서 SARS-CoV-2 공격에 대한 보호 반응 유도에 대한 최적화된 서열과 SARS-CoV-2의 스파이크 단백질 야생형 DNA 서열의 비교Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acid Against Antiviral binding breath CD4 CD8+ cellular immune responses cellular immunity challenge clinical trial contributing to COVID-19 CTL demonstrated DNA DNA vaccine expression full-length spike protein hACE2 humoral humoral and cellular immunity IFN-γ immune immune responses immunogen in vitro induction mice Model mouse Neutralizing antibodies optimization optimizations pGX-9501 platform Protective Protective effects protective response RBD binding response robust SARS-CoV-2 sequence spike Spike protein subsequent T cell T cells the vaccine Transgenic mouse Type virus wild-type wild-type sequence. [DOI] 10.1080/21645515.2021.2016201 PMC 바로가기 [Article Type] Article
Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2기계 학습과 결합된 펩티드 마이크로어레이는 SARS-CoV-2에 대한 중화 기능을 가진 인간 항체 반응의 개별 에피토프를 나타냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] anti-SARS-CoV-2 antibody Antibody binding assays binding epitope capture causative agent cellular coronavirus coronavirus SARS-CoV-2 Course COVID-19 detectable epitope Epitopes human antibody response IgA IgG IgM antibody immunoassays incubated infected with SARS-CoV-2 machine learning Microarray N-terminus negative control samples neutralization neutralization assays Neutralizing Neutralizing antibodies nine overlapping Patient peptide peptide arrays peptides positive protective effect Protective effects random Random forest response S protein SARS CoV SARS CoV-2 SARS-CoV-2 sera serology Serology. Specific structural protein structural proteins the disease the S protein vaccine candidate vaccine candidates Viral [DOI] 10.1080/22221751.2022.2057874 PMC 바로가기 [Article Type] Article
Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds양이온성 양친매성 스테로이드 화합물의 항 SARS-CoV-2 활성의 확인 및 특성화Article Published on 2022-12-012022-09-11 Journal: Virulence [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] aggravation ameliorated anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity Antiviral antiviral activity cationic caused cell lines characterization cholesterol complex Compound compounds COVID-19 pandemic COVID-19 patient cytopathic Cytopathic effect Drug discovery effective envelope envelope proteins epiandrosterone followed by hACE2 HEK293 host cell host cells identification in vitro in vivo indicated inhibited initial involved life Lipid mechanism membrane modulate modulation Mortality Pathogenesis progeny protective effect Protective effects Proteins Quality of life reduce reduce COVID-19 aggravation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected Selection single mutation single mutations specific treatment spike steroidal compounds. subversion Transgenic mouse translate transmembrane Treatment treatment of COVID-19 patients Vero Vero CCL81 cell Vero CCL81 cells viral replication Viral RNA viral variant Viral variants [DOI] 10.1080/21505594.2022.2085793 PMC 바로가기 [Article Type] Article
Protective role of zinc in the pathogenesis of respiratory diseases Reviews Published on 2022-08-182022-10-05 Journal: European journal of clinical nutrition [Category] 치료제, [키워드] Analysis Anti-inflammatory antioxidant Antiviral Apoptosis cancer cell disease Effect highlight immune In vitro studies Inflammation inhibit lipid metabolism Lung diseases Lungs morbidity and mortality oxidative stress Pathogenesis Perspective Protective effects protective mechanism provide regulate Regulation Research respiratory Respiratory disease respiratory diseases subjects therapy variety [DOI] 10.1038/s41430-022-01191-6 [Article Type] Reviews
Rapid evaluation of COVID-19 vaccine effectiveness against symptomatic infection with SARS-CoV-2 variants by analysis of genetic distance유전적 거리 분석을 통한 SARS-CoV-2 변이체의 증상 감염에 대한 COVID-19 백신 효과의 신속한 평가Article Published on 2022-08-012022-09-11 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, [키워드] 95% prediction interval accounted acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed applied circulating clinical trial collected Concordance coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine delta variant Effectiveness Efficacy Genetic Genetic variant highest lowest mixed-effects model mRNA vaccine observational study offer omicron pandemic platform predict predicted Predictive protective effect Protective effects Public health responses Rapid real time Receptor-binding domain regions reported SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 spike protein SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Spike protein symptomatic infection the receptor-binding domain the SARS-CoV-2 the vaccine Vaccine vaccine platform vaccine strain variant variants of concern virus [DOI] 10.1038/s41591-022-01877-1 PMC 바로가기 [Article Type] Article
The magnitude and timing of recalled immunity after breakthrough infection is shaped by SARS-CoV-2 variantsSARS-CoV-2 변종에 의해 형성되는 돌발성 감염 후 면역 회수의 규모와 시기Article Published on 2022-07-122022-09-11 Journal: Immunity [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Activation antibody Antibody titers B cell B cell immunity B cells Breakthrough infection breakthrough infections CD4 CD4 T cell immunity CD8 CD8 T cell immunity cellular immunity Clinical outcome clinical outcomes COVID-19 COVID-19 vaccines Delta humoral immune Immunity Immunological memory IMPROVE increase in infecting Infection lack magnitude Neutralizing Neutralizing antibodies neutralizing antibody titers omicron phenotypic potential mechanism PROTECT protective effect Protective effects provide recall recalled response robust SARS-CoV-2 SARS-CoV-2 variant seropositive individual seropositive individuals severe COVID-19 T cell the timing vaccinated individuals vaccination vaccination. variant Viral viral clearance viral replication while [DOI] 10.1016/j.immuni.2022.05.018 PMC 바로가기 [Article Type] Article
Clinical characteristics and immune profile alterations in vaccinated individuals with breakthrough Delta SARS-CoV-2 infectionsDelta SARS-CoV-2 감염이 있는 백신을 접종한 개인의 임상 특성 및 면역 프로필 변경Article Published on 2022-07-092022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 바이오마커, 변종, 임상, 치료기술, [키워드] absorbance accelerated alteration Breakthrough infection breakthrough infections Characteristics clinical clinical recovery comparable Course cytokine Cytokine storms Delta delta variant facilitate groups Guangzhou Immune profile immunization Inactivated vaccine Inactivated Vaccines Inflammation Local median mononuclear cell observé outbreak PBMCs Peripheral blood Peripheral blood mononuclear cells Pneumonia protective effect Protective effects reduce reduced reported SARS-COV-2 infection significantly the disease transcription profile Transmission unique vaccinated individual vaccinated individuals vaccination Vaccine vaccine group Viral pneumonia viral RNA clearance viral titer VoC [DOI] 10.1038/s41467-022-31693-7 PMC 바로가기 [Article Type] Article
Cyanidin-3-O-glucoside and Peonidin-3-O-glucoside-Rich Fraction of Black Rice Germ and Bran Suppresses Inflammatory Responses from SARS-CoV-2 Spike Glycoprotein S1-Induction In Vitro in A549 Lung Cells and THP-1 Macrophages via Inhibition of the NLRP3 Inflammasome Pathway시아니딘-3-O-글루코사이드 및 피오니딘-3-O-글루코사이드-풍부 검정 쌀 배아 및 겨 분획은 A549 폐 세포 및 THP-1 대식세포에서 SARS-CoV-2 스파이크 당단백질 S1-유도 시험관 내 염증 반응을 억제합니다 NLRP3 Inflammasome 경로의 억제Article Published on 2022-06-302022-09-11 Journal: Nutrients [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] A549 Activation anthocyanin anthocyanins Anti-inflammation anti-inflammatory property ASC attenuate benefit black black rice bran C3G Cell cell lines Concentration counteraction COVID-19 COVID-19 infection cytokine secretion dose-dependent manner downregulation Effect exhibited exposure to fraction functional functional food Gene Expression Germ Health health benefits HPLC IL-18 IL-1β IL-6 immune cells in vitro model Inflammasome Inflammation Inflammatory Inflammatory response Inflammatory responses inhibition innate immune cell Innate immune cells long-COVID lung tissue Macrophage macrophages mechanism NF-kB NLRP3 NLRP3 inflammasome P3G pathway post-acute COVID protective effect Protective effects Protein protein level protein levels reported response responsible Rice S1 subunit SARS-CoV-2 spike spike glycoprotein spike glycoprotein S1. THP-1 treated was determined [DOI] 10.3390/nu14132738 PMC 바로가기 [Article Type] Article
Virucidal Properties of Photocatalytic Coating on Glass against a Model Human Coronavirus모델 인간 코로나바이러스에 대한 유리의 광촉매 코팅의 바이러스 살균 특성Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료제, [키워드] added aerosol alteration Antiviral antiviral activity can not coated with coating construction Contact Contagion Contamination coronavirus coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 damaged deformation Disruption electron microscopy element Epidemiology Evidence evidence of exposure to glass human coronavirus Human coronavirus human coronaviruses in-depth analysis inactivation increase infectious investigated Kinetics knowledge Masks Microscopy mitigate Model morphologically pandemic performed Photocatalysis photocatalytic coating physical physical barrier property Protective protective effect Protective effects reduced reducing Research SARS-CoV-2 Spread suggested surface titanium titanium dioxide Transmission viral envelope virion virions virucidal virucidal activity. virus virus virus spread virus titer viruses [DOI] 10.1128/spectrum.00269-22 PMC 바로가기 [Article Type] Article
Anti-MDA5 Antibody Linking COVID-19, Type I Interferon, and Autoimmunity: A Case Report and Systematic Literature ReviewCOVID-19, I형 인터페론 및 자가면역을 연결하는 항MDA5 항체: 증례 보고 및 체계적인 문헌 검토Case Reports Published on 2022-06-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Activation anti-MDA5 syndrome antibody antiviral role Autoimmune Autoimmune disease Autoimmune diseases Cardiomyopathy Clinical features constitutional symptoms contribute correlated COVID-19 COVID-19 severity Cytokines differentiation antigen disease Disease activity elevated example explain Features IFN immune immune response immunological immunology in some induce Inflammatory inflammatory myositis interferons literature lung involvement Manifestations MDA5 mechanisms Melanoma myositis Patient Pattern recognition pattern recognition receptor protective effect Protective effects recognizing report review SARS-CoV-2 infected patients SARS-COV-2 infection searched severity signature similarities similarity skin manifestations Symptoms syndrome synthesis Trigger Type Type I IFN type I interferon type I interferon signature. type I interferons Viral viral infections virus viruses while with COVID-19 [DOI] 10.3389/fimmu.2022.937667 PMC 바로가기 [Article Type] Case Reports